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  Location: Home / Personnel / Publications Monday, September 06, 2010

Publications:

  1. Sielken, R.L. Jr. (1973). Stopping Times for Stochastic Approximation Procedures, Zeitschrift fur Wahrscheinlichkeitstheorie und Verwandte Gebiete, 26, 67‑75.
  2. Sielken, R.L. Jr. (1973). Sequential Sampling and Maximum Likelihood Estimation, Communications in Statistics, 1, 567‑568.
  3. Sielken, R.L. Jr. and Hartley, H.O. (1973). Two Linear Programming Algorithms for Unbiased Estimation of Linear Models, Journal of the American Statistical Association, 68, 638‑641.
  4. Hartley, H.O. and Sielken, R.L. Jr. (1975). A Super‑Population Viewpoint for Finite Population Sampling, Biometrics, 31, 411‑422.
  5. Sielken, R.L. Jr., (1975). Book Review: Practical Linear Programming with Computer Applications, by Michael O. Locks. Technometrics, 17, 514.
  6. Sielken, R.L. Jr. (1976). Sequencing with Setup Costs by Zero‑One Mixed Integer Linear Programming, AIIE Transactions, September, 369‑371.
  7. Hartley, H.O. and Sielken, R.L. Jr. (1977). Estimation of Safe Doses in Carcinogenic Experiments, Biometrics, 33, 1‑30.
  8. Sielken, R.L. Jr., Hartley, H.O. and Arseven, E. (1977). Critical Path Analysis in Stochastic Networks: Statistical PERT. SCIMA 6, No. 3.
  9. Hartley, H.O. and Sielken R.L. Jr. (1977). Response to Prof. Mantels Discussion of Presentation by Hartley and Sielken on the Estimation of Safe Doses and Carcinogenic Experiments, Journal of Environmental Pathology and Toxicology, 1, 267‑269.
  10. Burdick, R.K. and Sielken, R.L. Jr. (1978). Exact Confidence Limits for Linear Combinations of Variance Components in Nested Classifications, Journal of the American Statistical Association, 73, 632‑635.
  11. Burdick, R.K. and Sielken, R.L. Jr. (1979). Variance Estimation Based on a Super‑Population Model in Two‑Stage Sampling, Journal of the American Statistical Association, 74, 438‑440.
  12. Sielken, R.L. Jr. and Hartley, H.O. (1979). A New Statistical Approach to Project Scheduling, Decision Information, ed. by C.P. Toskos and R.M. Thrall, 153‑184.
  13. Baker, T.C. Jr. and Sielken, R.L. Jr. (1981). On Estimating a Discrete Distribution Function with Some Jump Sizes Known, Communications in Statistics, B10(2), 109‑128.
  14. Baker, T.C. Jr. and Sielken, R.L. Jr. (1981). Estimation of a Distribution Function by Extrapolating Upper and Lower Bounds, Communications in Statistics, B10(1), 77‑93.
  15. Hartley, H.O., Tolley, H.D., and Sielken, R.L. Jr. (1981). The Product Form of the Hazard Rate Model in Carcinogenic Testing, Statistics and Related Topics, 185‑200. M. Csorgo, D.A. Dawson, J.N.K. Rao, and A.K. Md. E. Saleh (eds.), North Holland, New York.
  16. The SOT ED01 Task Force (1981). Re‑Examination of the ED01 Study: Risk Assessment Using Time, Fundamental and Applied Toxicology, 1, 88‑123.
  17. Sielken, R.L. Jr. (1982). Which Options Provide the Quickest Solution, Evaluating Mathematical Programming Techniques, 135‑145. Edited by John M. Mulvey. Volume 199 in Lecture Notes in Economics and Mathematical Systems, Springer‑Verlag, New York.
  18. Sielken, R.L. Jr. (1982). Formaldehydes Low Dose Cancer Risk Extrapolation Using the Multistage Model and GLOBAL 79, Formaldehyde: Review of Scientific Basis of EPAs Carcinogenic Risk Assessment, Hearing Before the Subcommittee on Investigations and Oversight of the Committee on Science and Technology U.S. House of Representatives Ninety‑Seventh Congress Second Session, May 20, pp: 586‑749.
  19. Krewski, D., Crump, K.S., Gaylor, D.W., Portier, C., Salsburg, D., Sielken, R.L. Jr. and Van Ryzin, J. (1983). A Comparison of Statistical Methods for Low‑Dose Extrapolation Utilizing Time to Tumor Data, Fundamental and Applied Toxicology, 3:140‑158.
  20. The SOT ED01 Task Force (1983). The SOT Task Force Response to the NCTR Letter, Fundamental and Applied Toxicology, 3, 9‑12.
  21. Sielken, R.L. Jr. and Smith, L.A. (1983). Cancer Dose‑Response Models, Developments in the Science and Practice of Toxicology, A.W. Hayes, R.C. Schnell, and T.S. Miya, eds., 173‑180.
  22. Sielken, R.L. Jr. and Gbur, E.E. (1984). Multiyear, Through‑the‑Season Crop Acreage Estimation Using Estimated Acreage in Sample Segments, Communications in Statistics, 13, (23), 2961‑2974.
  23. Monroe, H.M. and Sielken, R.L. Jr. (1984). Confidence Limits for Global Optima Based on Near‑Optimal Solutions to Difficult Integer and Nonlinear Optimization Problems, American Journal of Mathematical and Management Sciences, 4, (1, 2), 139‑167.
  24. Sielken, R.L. Jr. (1985). The Use of the Hartley‑Sielken Model in Low Dose Extrapolation, Toxicological Risk Assessment, ed. by D. Clayson, D. Krewski, and I. Munro. Volume 1, Chapter 8, 165‑185. CRC Press, Inc., Boca Raton, Florida.
  25. Sielken, R.L. Jr. (1985). Some Issues in the Quantitative Modeling Portion of Cancer Risk Assessment, Regulatory Toxicology and Pharmacology, 5, 175‑181.
  26. Sielken, Robert L. Jr. (1985). Some Capabilities, Limitations, and Pitfalls in the Quantitative Risk Assessment of Formaldehyde, Risk Analysis in the Chemical Industry, 74‑122.
  27. Sielken, R.L. Jr. (1986). Implications of the Time‑to‑Response Information, Hazard Assessment of Ethylene Oxide, ed. by L. Golberg, 125‑165. CRC Press, Inc., Boca Raton, Florida.
  28. Sielken, R.L. Jr. (1986). The Capabilities, Sensitivity, Pitfalls, and Future of Quantitative Risk Assessment, Environmental Health Risks: Assessment and Management, 95‑131, ed. by R. Stephen McColl. University of Waterloo Press, Waterloo, Ontario.
  29. Sielken, R.L. Jr. (1987) The Forthcoming Merger in Quantitative Risk Assessment, Food Protection Technology, ed. by C.W. Felix, Lewis Publishers, 251‑288. Proceedings of the 1986 Conference for Food Protection, August 1986, Ann Arbor, Michigan.
  30. Sielken, R.L. Jr. (1987) Cancer Dose-Response Extrapolations, Environmental Science and Technology, Vol. 21, No. 11, 1033-1039.
  31. Sielken, R.L. Jr. (1987) Statistical Evaluations Reflecting the Skewness in the Distribution of TCDD Levels in Human Adipose Tissue, Chemosphere, Vol. 16, No 8/9, 2135‑2140.
  32. Sielken, R.L. Jr. (1987) Quantitative Cancer Risk Assessments for 2,3,7,8‑Tetrachlorodibenzo‑p‑Dioxin (TCDD), Food and Chemical Toxicology, Vol. 25, No.3, pp.257‑267.
  33. Sielken, R.L. Jr. (1988) A Critical Evaluation of a Dose‑Response Assessment for TCDD, Letters to the Editor, Food and Chemical Toxicology, Vol. 26, No. 1, pp. 80‑83.
  34. Austin, S.G. and Sielken, R.L. Jr. (1988) Issues in Assessing the Carcinogenic Hazards of Ethylene Oxide, Journal of Occupational Medicine, Vol. 30, No. 3, pp. 236‑245.
  35. Smith, L.A. and Sielken, R.L. Jr. (1988) Bootstrap Bounds for Safe Doses in Quantitative Risk Assessment, Communications in Statistics, Part B. Simulation and Computation, Vol. 17, No. 1, pp. 153‑175.
  36. Sielken, R.L. Jr. Benzene and Leukemia: Opposed to the Shortcomings in the Current Regulatory Process, Grappling with Risk Assessment: On the Frontier of Science and Law.
  37. Sielken, R.L. Jr. (1989) A Time‑to‑Response Perspective on Ethylene Oxides Carcinogenicity, The Risk Assessment of Environmental and Human Health Hazards: A Textbook of Case Studies, pp. 174‑237, ed. by D.J. Paustenbach. John Wiley & Sons, Inc. Publishers, New York. (1989).
  38. Sielken, R.L. Jr. (1989) Combining Physiology, Carcinogenic Mechanism, and Interindividual Variation in Cancer Dose‑Response Extrapolations, Risk Assessment in Setting National Priorities, 43‑58, ed. by James J. Bonin and Donald E. Stevenson. Plenum Press, New York.
  39. Sielken, R.L. Jr. A General Tool for Incorporating Interspecies Extrapolation Information into Quantitative Cancer Risk Assessment, Proceedings of the ACT / SRA Workshop on Inferring Carcinogenic Effects in One Species from Data on a Different Species. The Teleford Press.
  40. Sielken, R.L. Jr. (1989) Useful Tools for Evaluating and Presenting More Science in Quantitative Cancer Risk Assessments, Toxic Substances Journal, Vol. 9, 353‑404. Hemisphere Publishing Corporation.
  41. Sielken, R.L. Jr. (1990) Driving Cancer Dose‑Response Modeling with Data Not Assumptions, Letter to the Editor, Risk Analysis, Vol. 10, No. 2, 207‑208.
  42. Sielken, R.L. Jr. (1990) Incorporating More Science into Cancer Dose‑Response Extrapolations, New Risks, 87‑94, ed. by L.A. Cox Jr. and P.F. Ricci, Plenum Press, New York.
  43. Sielken, R.L. Jr. (1990) Decision Analysis and Quantitative Risk Characterization: Information‑Analysis Based Risk Characterization. Chemical Manufacturers Association, Inc., Washington, D.C.
  44. Sielken, R.L. Jr. (1990) A Weight‑of‑Evidence Approach to Quantitative Cancer Risk Assessment: Information Analysis, Risk Assessment in Chemical Carcinogenesis, ed. by G. Schettler, D. Schmhl, and T. Klenner, Springer-Verlag, New York. Proceedings of the Satellite Symposium on Risk Assessment in Chemical Carcinogenesis, Heidelberg, Germany August 24-25, 1990.
  45. Sielken, R.L. Jr. Quantitative Cancer Dose‑Response Modeling for All Ages,Risk Analysis: Prospects and Opportunities, ed. by C. Zervos, Plenum Press, New York.
  46. Sielken, R.L. Jr. (1991) New Approaches and Tools for Quantitative Cancer Risk Assessment, The Analysis, Communication, and Perception of Risk, pp. 677‑692, ed. by B.J. Garrick and W.C. Gekler, Plenum Press, New York
  47. Lu, Frank C. and Robert L. Sielken Jr. (1991) Procedures for Assessment of Safety / Risk of Chemicals: Inception and Evolution of the ADI and Dose‑Response Modeling Procedures, Toxicology Letters, 59, pp. 5‑40.
  48. Sielken, Robert L., Jr. and Donald E. Stevenson (1992) Comparisons of Human Cancer Potency Projections for Dieldrin Based on Human Data with those Based on Animal Data, Relevance of Animal Studies to Evaluate Human Cancer Risk, pp. 295-319, ed. by Robert D'Amato, Thomas J. Slaga, William H. Farland, and Carol Henry, John Wiley & Sons, Inc., New York.
  49. Holland, Charles D. and Robert L. Sielken Jr. (1993) Quantitative Cancer Modeling and Risk Assessment, Prentice Hall, Englewood Cliffs, New Jersey.
  50. Sielken, Robert L., Jr., Robert S. Bretzlaff, and Donald E. Stevenson (1994). Incorporating Additional Biological Phenomena Into Two-Stage Cancer Models,@ Receptor-Mediated Biological Processes Implications for Evaluating Carcinogenesis, pp. 237-260, ed. by Hugh L. Spitzer, Thomas J. Slaga, William F. Greenlee, and Michael McClain, Wiley-Liss, New York.
  51. Sielken, Robert L., Jr. (1993) Evaluation of Chloroform Risk to Humans, The Toxicology Forum, 1993 Annual Winter Meeting, February 15-17, 1993, The Capitol Hilton, Washington, D.C.
  52. Sielken, Robert L., Jr. (1993) Background Carcinogenicity Rates, The Toxicology Forum, 1993 Annual Summer Meeting, July 12-16, 1993, Given Institute of Pathology, Aspen, Colorado.
  53. Evans, John S., John D. Graham, George M. Gray, and Robert L. Sielken Jr. (1994) A Distributional Approach to Characterizing Low-Dose Cancer Risk, Risk Analysis, Vol. 14, No. 1, pp. 25-34.
  54. Sielken, Robert L., Jr. and Donald E. Stevenson (1994) Another Flaw in the Linearized Multistage Model Upper Bounds on Human Cancer Potency, Regulatory Toxicology and Pharmacology, Vol. 19, pp. 106-114.
  55. Evans, John S., George M. Gray, Robert L. Sielken Jr., Andrew E. Smith, Ciriaco Valdez-Flores, John D. Graham (1994) Use of Probabilistic Expert Judgment in Distributional Analysis of Carcinogenic Potency, Regulatory Toxicology and Pharmacology, Vol. 20, Number 1, 15-36.
  56. Stevenson, Donald E., Robert L. Sielken Jr., and Robert S. Bretzlaff (1994) Challenges To Low-Dose Linearity In Carcinogenesis From Interactions Among Mechanistic Components As Exemplified By The Concept of Invaders and Defenders, Belle Newsletter, Vol. 3, Number 2, 1-8.
  57. Stevenson, Donald E., Robert S. Bretzlaff, Robert L. Sielken Jr., and Ross L. Macdonald (1994) Dose-Response Characterization of Life, Death, and Hormesis, Comments Toxicology, Vol. 5, No. 2, pp. 151-180.
  58. Sielken, Robert L. Jr. (1995) How to use both human and animal data in quantitative risk Assessment, The Role of Epidemiology in Regulatory Risk Assessment, pp. 105-123, ed. by John D. Graham, Elsevier, New York.
  59. Sielken, Robert L. Jr., Robert S. Bretzlaff, and Donald E. Stevenson (1995) Challenges to Default Assumptions Stimulate Comprehensive Realism as a New Tier in Quantitative Cancer Risk Assessment, Regulatory Toxicology and Pharmacology, 21, 270-280.
  60. Stevenson, Donald E. and Robert L. Sielken Jr. (1995) Incorporating the Concept of Invaders and Defenders in the Dose-Response Modeling of Carcinogens, Growth Factors and Tumor Promotion: Implications for Risk Assessment, pages 445-451, Wiley-Liss, New York.
  61. Sielken, Robert L., Jr. and Barbara A. Trenary (1995) More Realistic Exposure Durations for More Realistic People, Risk Analysis, (to appear).
  62. Sielken, Robert L., Jr. and Barbara A. Trenary (1995), More Realistic Exposure Durations for More Realistic People, Proceedings of the Air and Waste Management Association meeting in San Antonio, Texas, June, 1995.
  63. Clifford, Philip A., Daniel E. Barchers, David F. Ludwig, Robert L. Sielken Jr., J. Scott Klingensmith, Richard V. Graham, and Marcy I. Banton (1995) Hazard/Risk Assessment: An Approach to Quantifying Spatial Components of Exposure for Ecological Risk Assessment, Environmental Toxicology and Chemistry, Vol. 14, No. 5, pp. 895-906.
  64. Evans, John S., John D. Graham, George M. Gray, and Robert L. Sielken Jr. (1995) A Distributional Approach to Characterizing Low-Dose Cancer Risk, Low-Dose Extrapolation of Cancer Risks, pp. 253-274, ed. by Stephen Olin, William Farland, Colin Park, Lorenz Rhomberg, Robert Scheuplein, Thomas Starr, and James Wilson, ILSI Press, Washington, D.C.
  65. Preston, R. Julian, Timothy R. Fennell, A. Philip Leber, Robert L. Sielken Jr, and James A. Swenberg (1995) Reconsideration of the Genetic Risk Assessment for Ethylene Oxide Exposures, Environmental and Molecular Mutagenesis, Vol. 26, pp. 189 - 202.
  66. Astill, B.D., R. Gingell, D. Guest, J. Hellwig, J.R. Hodgson, K. Kuettler, W. Mellert, S.R. Murphy, R.L. Sielken, and T.R. Tyler (1996) Oncogenicity Testing of 2-Ethylhexanol in Fischer 344 Rats and B6C3F1 Mice, Fundamental and Applied Toxicology, Vol. 31, pp. 29 - 41.
  67. Sielken, Robert L., Jr., Richard H. Reitz, and Sean M. Hays (1996) Using PBPK Modeling and Comprehensive Realism Methodology for the Quantitative Cancer Risk Assessment of Butadiene, Proceedings of the International Symposium on the Evaluation of Butadiene & Isoprene Health Risks, June 27-29, 1995, Toxicology, 113, pp. 231-237.
  68. Sielken, Robert L., Jr., and Ciriaco Valdez-Flores (1996) Comprehensive Realisms Weight-of-Evidence Based Distributional Dose-Response Characterization, Special Issue of the Journal of Human and Ecological Risk Assessment on: Theoretical, Toxicological and Biostatistical Foundations for Deriving Probability Distribution Functions for Reference Doses and Benchmark Doses with Application to Carcinogens and Noncarcinogens, Vol. 2, No. 1, pp. 175-193.
  69. Sielken, Robert L., Jr., and Ciriaco Valdez-Flores (1995) Comprehensive Realisms Use of Trees and Distributions to Reflect Uncertainty and Variability and to Overcome the Limitations of Default Assumptions, Special Issue of the Journal of Energy Engineering on: New Methods to Deal with Uncertainty and Applications in Assessing Energy Systems, ed. by Paolo F. Ricci. (to appear)
  70. Soden, Kevin J., Jonathan Amsel, Robert L. Sielken Jr., and Ciriaco Valdez-Flores (1996) Carboxyhemoglobin Levels in Workers Exposed to Methylene Chloride as Compared to a PBPK Model, (submitted).
  71. Sielken, Robert L., Jr. (1996) Comprehensive Realism: Industrys Emerging Approach to Risk Assessment and Managing Environmental Compliance, Proceedings of ASSE / AIHA / NREP Environmental Symposium, Risk vs. Resource Allocation:Environmental Decision Making, February 5-6, 1996.
  72. Banton, Marcy I., J. Scott Klingensmith, Daniel E. Barchers, Philip A. Clifford, David F. Ludwig, A. Michael Macrander, Robert L. Sielken Jr., and Ciriaco Valdez-Flores (1996) An Approach for Estimating Ecological Risks from Organochlorine Pesticides to Terrestrial Organisms at Rocky Mountain Arsenal, Human and Ecological Risk Assessment, Vol. 2, No. 3, pp. 499-526.
  73. Sielken, Robert L., Jr. and Donald E. Stevenson (1997) Opportunities to Improve Quantitative Risk Assessment, Human and Ecological Risk Assessment, Vol. 3, No. 4, pp. 479-489.
  74. Sielken, Robert L., Jr. and Donald E. Stevenson (1998) Some Implications for Quantitative Risk Assessment if Hormesis Exists, Human & Experimental Toxicology, Vol. 17, pp. 259-262.
  75. Sielken, Robert L., Jr., Robert S. Bretzlaff, Donald E. Stevenson, and Geert de Jong (1998) Updated Mortality Analyses of Pernis Epidemiological Data on Human Exposures to Aldrin and Dieldrin, Human and Ecological Risk Assessment, Vol. 4, No. 1, pp. 201-225.
  76. Sielken, Robert L., Jr. and Donald E. Stevenson (1998) Modeling to Incorporate Defense Mechanisms into the Estimation of Dose Responses, Environmental Health Perspectives, Vol. 106, Supplement 1, pp. 341-348.
  77. Sielken, Robert L., Jr., Robert S. Bretzlaff, and Ciriaco Valdez‑Flores (1998). Probabilistic Risk Assessment for Atrazine and Simazine in Triazine Herbicides: Risk Assessment, ACS Symposium Series 683, Ed. Larry G. Ballantine, Janis E. McFarland, and Dennis S. Hackett, American Chemical Society, Oxford University Press.
  78. Sielken, Robert L., Jr. and Ciriaco Valdez‑Flores (1999). Probabilistic Risk Assessments Use of Trees and Distributions to Reflect Uncertainty and Variability and to Overcome the Limitations of Default Assumptions, Special Issue of Environmental International on: Modeling and Simulation. Vol. 25, pp. 755-772.
  79. Stevenson, Donald E., Earl F. Walborg, Jr., D. Warner North, Robert L. Sielken, Jr, C. E. Ross, Alan S. Wright, Yong Xu, Lisa M. Kamendulis, and James E. Klaunig (1999). Monograph: Reassessment of Human Cancer Risk of Aldrin/Dieldrin, Toxicology Letters, Vol. 109, pp. 123-186.
  80. Sielken, Robert L., Jr., Robert S., Bretzlaff, Ciriaco Valdez-Flores, Donald E. Stevenson, and Geert de Jong (1999). Cancer Dose-Response Modeling of Epidemiological Data on Worker Exposures to Aldrin and Dieldrin, Risk Analysis, Vol. 6, pp. 1101-1111.
  81. Teta, Jane M., Robert L. Sielken, Jr., and Ciriaco Valdez-Flores (1999). Ethylene Oxide Cancer Risk Assessment Based on Epidemiological Data: Application of Revised Regulatory Guidelines, Risk Analysis Vol. 6, pp. 1135-1155.
  82. Chaisson, Chirstine F., Robert L. Sielken, Jr., and William J. Butler (1999). Overestimation Bias and Other Pitfalls Associated with the Estimated 99.9th Percentile in Acute Dietary Exposure Assessments, Regulatory Toxicology and Pharmacology, Vol. 29, No. 2, pp. 102-127.
  83. Sielken, Robert L., Jr. (2000). Risk Metrics and Cumulative Risk Assessment Methodology for the FQPA Regulatory Toxicology and Pharmacology, Vol. 31, pp. 300-307.
  84. Stevenson, Donald E. and Robert L. Sielken, Jr. (2000). Are Calories Responsible for a Decline in Longevity? Human & Experimental Toxicology, Vol. 19, pp. 348-350.
  85. Sielken, Robert L., Jr. and Ciriaco Valdez-Flores (2001). Dose-Response Implications of the University of Alabama Study of Lymphohematopoietic Cancer Among Workers Exposed to 1,3-Butadiene, Styrene, and Dimethyldithiocarbamate in the Synthetic Rubber Industry, Chemico-Biological Interactions, Vol. 135-136, pp. 637-651.
  86. Amsel, Jonathan, Kevin J. Soden, Robert L. Sielken Jr., and Ciriaco Valdez‑Flores (2001). Observed versus Predicted Carboxyhemoglobin Levels in Cellulose Triacetate Workers Exposed to Methylene Chloride, American Journal of Industrial Medicine, Vol. 40, pp. 180-191.
  87. Valdez-Flores, Ciriaco, Larry R. Holden, and Robert L. Sielken, Jr. (2002). Generating Single-Unit Residue Concentration Distributions based on Maximum Likelihood Estimation from Composite Data. Environmetrics, Vol. 13, pp. 711-724.
  88. Sielken, Robert L. Jr., Ciriaco Valdez-Flores, Larry R. Holden, Charles Breckenridge, and James Stevens. (2003). "Statistical Inferences about the Mechanism of Action in Carcinogenicity Studies." Accepted for Scandinavian Journal of Work, Environment & Health.
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