DOSE-RESPONSE MODELS

The terminology dose-response model is commonly used to mean either a family of dose-response models or a specific member of the family of dose-response models.  The context usually identifies which meaning is applicable.  A family of dose-response models is a collection of models all with the same general parametric or functional form  (e.g., the family of all polynomials or the family of all straight lines).  A specific member of the family of dose-response models is one specific function with specific values given for all parameters (e.g., the straight line with intercept equal to zero and slope equal to one).

Some of the dose-response models that Sielken & Associates use and which are included in GEN.T include the following:

Linearized Multistage Model (Quantal Response Model)

Multistage Model (Quantal Response Model)

Weibull Model (Quantal Response Model)

Probit Model (Quantal Response Model)

Logit Model (Quantal Response Model)

Multihit Model (Quantal Response Model)

Multistage Model with Cumulative Dose (Quantal Response Model)

Armitage-Doll Model (Time-to-Response Model)

Two-Stage Growth Model (Time-to-Response Model)

            also known as the Moolgavkar-Venzon-Knudsen (MVK) Model

Generalized Hartley-Sielken Model (Time-to-Response Model)

Original Hartley-Sielken Model (Time-to-Response Model)

Gompertz-Makeham Model (Time-to-Response Model)