Cumulative Risk Assessment:

            The Food Quality Protection Act requires a cumulative risk assessment.  Cumulative risk is the risk due to the exposure to all substances that have a common mechanism of toxicity.  Cumulative risk assessments combine the aggregate risks (from possibly multiple exposure pathways and routes) for all substances that have a common mechanism of toxicity.

            Sielken & Associates have helped develop methods that incorporate the relative potency or toxicological equivalence between substances into the cumulative risk assessment.  Toxicological equivalence factors can reflect the exposure duration (e.g., acute, intermediate, subchronic, or chronic)

            By using better characterizations of toxicological equivalence and probabilistic exposure characterizations, Sielken & Associates can help avoid the the multiple conservatisms associated with the regulatory default assessments that exaggerate cumulative risks.